Pentoprazole, under the brand name Protonix, is a class of drugs called proton pump inhibitors, or P. for short. پی. Oh you. PPIs, which reduce stomach acid production, are used to treat gastrointestinal problems such as acid reflux. In the following, you will get acquainted with the uses and side effects and important points related to pantoprazole. Stay with us until the end of the article.
Indications for pantoprazole
Pantoprazole relieves symptoms such as heartburn, difficulty swallowing, and persistent cough by reducing the production of stomach acid. It also helps heal acid-induced damage to the stomach and esophagus and prevents stomach ulcers and esophageal cancer. In addition, it is used to treat erosive esophagitis (esophageal injury from gastric acid due to gastroesophageal reflux disease (GERD)) in adults and children over 5 years of age, usually once a day for 8 weeks to improve esophagus. Find.
Pantoprazole is not for the immediate treatment of heartburn symptoms. Heartburn is usually one of the first signs of a heart attack.
If you have any of the following symptoms, call the emergency room right away; Because it may be a sign of a heart attack:
- General feeling of illness;
- Diffuse pain in the arm and shoulder;
- Chest pain or a feeling of heaviness;
How to take pantoprazole sodium
Follow your pharmacist’s advice before you start taking the medicine and every time you take the medicine again. Ask your doctor or pharmacist if you have any questions. Pantoprazole is available orally (tablets or granules) and by injection (intravenously). The amount of medication and duration of treatment depends on your condition and response to treatment.
- If you use a nasogastric tube or nasal tube to get granules, ask your doctor how to use it.
- You can take pantoprazole tablets with or without food. Swallow the tablet whole. Do not crush or crush the medicine or chew it. This may destroy the effect of the medicine.
- Take pantoprazole granules 30 minutes before a meal. You can pour the granules in apple puree or apple juice and taste. However, do not mix it with other foods and beverages. Do not crush or crush the granules. Pour 1 teaspoon of granules into apple puree and drink immediately for 10 minutes, then drink a sip of water or pour it in apple juice, stir for 5 seconds and drink the whole. To ensure the consumption distance, pour apple juice in the same glass again and drink it. Do not prepare your next medication sooner.
Important points about taking pantoprazole
- Talk to your doctor if your illness persists or gets worse. The risk of side effects increases over time.
- It may be given with antacids if needed. If you are using sucralfate, take pantoprazole at least 30 minutes before sucralfate.
- Take the medicine regularly to have the right effect. To prevent forgetfulness, you can take the medicine at a specific time each day. Even if you feel better, complete the course of treatment.
Dosage of pantoprazole for adults
Dosage of pantoprazole for erosive esophagitis
- 40 mg orally, once daily, for 8 weeks. Depending on the patient’s condition, treatment may last up to 16 weeks. The safety and efficacy of the drug have not been evaluated for more than 16 weeks.
Dosage of pantoprazole for gastroesophageal reflux disease
- Injection type: 40 mg, once a day, for 7 to 10 days. Intravenous injections for 15 minutes are recommended and should be taken orally as soon as the patient is able to use the pill.
- Oral type: 40 mg, once a day, for 8 to 16 weeks.
Dosage of pantoprazole for duodenal ulcer disease
- 40 mg orally, once a day. The dose is increased by 40 mg once every 12 weeks; So that it reaches 120 mg in 28 weeks.
Dosage of pantoprazole for gastric ulcer
- 40 mg orally, once a day, which after 4 to 8 weeks can completely cure gastric ulcer.
Dosage of pantoprazole for Helicobacter pylori infection
- 40 mg orally, twice daily, for 7 days, with bismuth subcitrate and tetracycline, both 4 times daily and metronidazole 200 mg, 3 times daily and 400 mg at bedtime.
Dosage of pantoprazole for Zollinger-Edison syndrome
- Injection: 80 mg every 12 hours for 15 minutes.
- Oral type: 40 mg, twice daily up to a maximum of 240 mg per day. Sometimes the treatment lasts up to 2 years.
Dosage of pantoprazole for stress wound prophylaxis
- 80 mg twice daily for 15 minutes, up to a maximum of 240 mg daily in 3 equal doses.
Forget the dose
If you miss a dose, take the missed dose as soon as you remember. However, if you are close to the time of the next dose, skip the missed dose. Avoid taking twice as much medicine.
If a person has an overdose of medication and has symptoms such as fainting or difficulty breathing, call the emergency number (115) immediately.
Side effects of pantoprazole
You may experience headaches or diarrhea with pantoprazole. If any of these symptoms persist or your symptoms get worse, talk to your doctor or pharmacist immediately. Remember that your doctor has prescribed the medicine according to your condition and taking into account the side effects of pantoprazole. On the other hand, many people who take pantoprazole do not have serious side effects.
Serious side effects of pantoprazole
- Causes or worsens joint pain.
- Symptoms of lupus, such as pimples on the nose and cheeks;
- Symptoms of magnesium depletion (abnormal heartbeat – which can be fast, slow or irregular – and persistent muscle spasms and seizures).
In rare cases, C. difficile bacteria may be present. (C. difficile) causes severe intestinal disease that can occur during treatment or weeks and months after stopping treatment. Consult your doctor if you have any of the following symptoms:
- Persistent diarrhea;
- Pain or cramping in the abdomen or stomach;
- The presence of mucus or blood in the stool;
- Kidney problems such as decreased urination or blood in the urine.
In rare cases, proton pump inhibitors such as pantoprazole cause vitamin B12 deficiency. If the drug is used every day for a long time (3 years or more), this is more likely to happen. Be sure to consult your doctor if you have symptoms of vitamin B12 deficiency. Symptoms of vitamin B12 deficiency include:
- Tongue sores;
- Unusual weakness;
- Numbness and tingling in the hands or feet.
A severe allergic reaction to pentopinazole is rare. However, if you have a severe allergic reaction, see your doctor right away. Symptoms of an allergic reaction include:
- Difficulty breathing;
- Severe dizziness;
- Symptoms of kidney problems such as changes in urine output;
- Itching or swelling (especially on the face, tongue or throat).
Drug interactions may alter drug performance or increase the risk of serious side effects. In this part of the article, only important and common drug interactions are mentioned. Be sure to make a list of the medications you are taking (including prescription, over-the-counter, and herbal remedies) and give them to your doctor. Do not start or stop taking any medication or change the dose without your doctor’s approval.
Some products require stomach acid to be fully absorbed by the body. Pantoprazole can affect the performance of these products by reducing stomach acid, which can be referred to the following drugs:
- Specific antifungals such as itraconazole, ketoconazole and posaconazole.
Use of pantoprazole in special cases
- Pantoprazole passes through breast milk. Consult a doctor before breastfeeding;
- Pantoprazole should be used during pregnancy only if necessary. Talk to your doctor about the risks and benefits of taking the drug;
- Elderly people may be exposed to the side effects of the drug, especially bone loss and fractures and C. difficile infection. Be more sensitive;
- Proton pump inhibitors such as pantoprazole may increase the risk of bone fractures; Especially if the dose is taken for a long time or in the elderly. To prevent this from happening, talk to your doctor about taking calcium supplements such as calcium citrate or vitamin D.
- Do not share the medicine with others;
- If the medicine expires, do not throw it in the sewage well and ask the pharmacist for help in disposing of it;
- Inform your doctor or dentist about the medications you are taking before surgery;
- Keep the medicine at room temperature away from light, moisture and heat and keep it out of the reach of children and animals;
- Tell your doctor about your medical history, such as liver disease, lupus, or osteoporosis, before taking pantoprazole.
- If your doctor prescribes regular and long-term use of the drug, it is necessary to perform regular laboratory tests to check the amount of magnesium, vitamin B12 and side effects caused by the drug;
- Tell your doctor before taking pantoprazole if you are allergic to pantoprazole, similar medicines such as lansoprazole or omeprazole, nexium, prevasid, prilosec, or anything else. This product may contain inactive ingredients that may cause an allergic reaction. Talk to your pharmacist for details.
Pantoprazole brand names in Iran
The following are some examples of Iranian-made pantoprazole:
- Pentochem 20 mg tablets produced by Hakim Pharmacy;
- Pentoprazole capsules 40 mg Pharmaceutical production of Iran Daru;
- Pantoprazole tablets 20 and 40 mg produced by Farabi Pharmacy;
- Pentus 20 and 40 mg tablets produced by Sami Saz Pharmaceuticals;
- Pantoprazole capsules 20 and 40 mg produced by Obaidi Pharmacy;
- Pantoprazole CD 40 mg ampoule produced by Kimidaro Pharmacy;
- Pentobiosol 20 and 40 mg tablets produced by Bakhtar Biochemical Pharmacy.
Do you have experience with pantoprazole? What kind of disease and with what dose do you use it? If you wish, you can share your experiences and opinions with us and your friends in the “Send Comment” section. You can also send this article to your loved ones through social media to learn more about this stomach acid reducing drug.